A virtual reality maze that ‘predicts Alzheimer’s disease’

A new study suggests that Alzheimer’s disease can be detected decades before onset, all through using a virtual reality test.

People aged 18 to 30 were asked to navigate through a virtual maze to test the function of certain brain cells.

According to German neuroscientists, those with a high genetic risk of Alzheimer’s could be identified by their performance.

In the journal Science, they said that they feel that these findings could help future research, diagnosis and treatment.

The scientists, led by Lukas Kunz of the German Centre for Neurodegenerative Diseases in Bonn, say the high risk group navigated the maze differently and had reduced functioning of a type of brain cell involved in spatial navigation.

He continued to explain that the findings could give an insight into why people with dementia can find navigating the world around them challenging.

“Our results could provide a new basic framework for preclinical research on Alzheimer’s disease and may provide a neurocognitive explanation of spatial disorientation in Alzheimer’s disease,” they reported in Science.

Although genes play a role in dementia, their effects are complex with many unknown outcomes.

Dr Laura Phipps of Alzheimer’s Research, said the latest study focused on healthy younger group of people who were still at a higher genetic risk of Alzheimer’s, suggesting they may already show alterations in spatial navigation several decades before the disease could start.

She added: “Although we don’t know whether the young people in this study will go on to develop Alzheimer’s, characterising early brain changes associated with genetic risk factors is important to help researchers better understand why some people may be more susceptible to the disease later in life.

“The risk factors for Alzheimer’s are diverse, including age, genetics and lifestyle, and research is vital to allow us to unpick how each of these factors could contribute to a person’s risk of the disease.”


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